Our researcher has identified alternative treatments for antibiotics
The article “Combatting antibiotic resistance in Gardnerella V: A comparative in silico investigation for drug target identification”, co-authored by Western Caspian University Vice-Rector for Scientific Affairs, PhD in Biology Saltanat Agayeva, was published in the Q1-rated journal “PLOS ONE” indexed in the Scopus database.
This bacterium is found in approximately 95% of gardnerellosis cases and creates treatment difficulties due to its resistance to multiple antibiotics. For this reason, the development of alternative therapeutic approaches has become necessary.
The study identified the virulence factors and potential drugs of the bacterium using in silico methods - subtractive and comparative genomics methods.
As a result of the study, the phospho-2-dehydro-3-deoxyheptonate aldolase enzyme was selected as a promising drug target and its structural-functional properties were studied in depth through modeling, validation and network analyses. A virtual screening of approximately 9,000 FDA-approved drug compounds was then conducted, and five effective compounds (DB03332, DB07452, DB01262, DB02076, and DB00727) were identified as potential therapeutics.
These compounds were shown to be effective against the bacteria and economically viable. However, further experimental studies are needed to fully validate the results.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314465
https://www.scopus.com/record/display.uri?eid=2-s2.0-86000779590&origin=recordpage